David Blue plays Eli Wallace, "Mathboy", on Stargate: Universe. Eli is the token SF fanboy in the crew of the Ancient spaceship Destiny. David Blue is credited with having inspired other Stargate cast members to join Twitter.

Elyse Levesque plays Chloe Chapman on Stargate: Universe. Chloe is a young, intelligent, beautiful woman who had no idea she would be flung halfway across the universe.

Patrick Gilmore plays Dale Volker on Stargate: Universe. Volker is one of the scientists who has been trapped on the Ancient spaceship Destiny.

Ming Na plays Camille Wray, a member of the International Oversight Committee that governs the Stargate program on behalf of all member nations. Camille has a background in human resources that should help her find a useful role in the Destiny's crew. She is the highest ranking civilian member of the Destiny crew.

Lou Diamond Phillips plays Colonel David Telford, who trades places via Ancient technology with Colonel Everett Young. Telford doesn't seem to think much of Young, probably because Telford was supposed to lead the Icarus expedition to explore the 9th chevron.